The laboratory of
Prof. Kyriakos E. Kypreos

Exploring the exciting world
of lipids and lipoproteins
for better health

The laboratory of
Prof. Kyriakos E. Kypreos

Clinical Pharmacology and Therapeutics

The laboratory of
Prof. Kyriakos E. Kypreos

Preclinical Research in animal models

The laboratory of
Prof. Kyriakos E. Kypreos

Consulting
Post-market evaluation
Product safety assesment

The laboratory of
Prof. Kyriakos E. Kypreos

Ideas and innovation
for healthy living

Research

Publications

e-Learning

Services

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In my research laboratory, currently located at the University of Patras Medical School, we have been performing for over 20 years, research in lipidology. Using unique animal models and advanced molecular approaches coupled with modern gene transfer methodologies, we explore the exciting world of lipoproteins for better health.
Our preclinical studies aim at unraveling the molecular links between the lipoprotein transport system and metabolic conditions such as dyslipidemia, obesity and diabetes. Among others, we place particular interest in the role of the lipoprotein system in adipose tissue metabolic activity. Ultimate goal of our studies is the identification of novel pharmacological targets and the creation of individualized therapies for these conditions.
Our clinical studies focus on the better understanding of pharmacotherapy in the treatment of metabolic conditions and the potential synergism between therapies for increased therapeutic efficacy. Along these lines, we provide consulting services to the Pharmaceutical industry, for post-marketing evaluation and safety assessment of their products. To increase the impact of our work, scientists of my research team come from numerous disciplines of biomedical research, contributing to an interdisciplinary approach to all projects.
In addition to our research, in this website you will be introduced to the members of the lab, our representative publications in international peer-reviewed journals, the research services we provide and the most important news from our lab and around the world. I strongly encourage you to take the time and watch our educational videos located in the e-Learning section of our website, to get a close-up look at our most novel research findings.

I would like to thank you for taking this virtual tour around my lab. I hope that you enjoy surfing our website.

Sincerely,
kyriakos kypreos signature

What’s New

Our manuscript entitled ‘High-Density Lipoprotein (HDL) metabolism and bone mass’ is now featured in the Journal of Endocrinology educational resources - JBL (Journal Based Learning)

Our manuscript entitled ‘High-Density Lipoprotein (HDL) metabolism and bone mass’ is now featured in the Journal of Endocrinology educational resources - JBL (Journal Based Learning)

03 August 2017

Our manuscript ‘High-Density Lipoprotein (HDL) metabolism and bone mass’ recently accepted for publication in the Journal of Endocrinology (IF=4.71, Official Journal of the Society for Endocrinology) has been selected to be featured in the journal’s educational resource – Journal Based Learning (JBL). JBL is being introduced to help educate clinicians-in-training and junior researchers. It is based upon leading articles published in the Journal of Endocrinology that form the evidence for continuing professional development programmes. Congratulations to all contributors for their good work!

Apolipoprotein C3, a critical apolipoprotein for hypertriglyceridemia, exerts pleiotropic effects on HDL Functionality and Adipose Tissue Metabolic Activity

Apolipoprotein C3, a critical apolipoprotein for hypertriglyceridemia, exerts pleiotropic effects on HDL Functionality and Adipose Tissue Metabolic Activity

14 July 2017

The Journal of Lipid Research, the official lipidology journal of ASBMB, yesterday published our work on the "Pleiotropic effects of apolipoprotein C3 on HDL functionality and adipose tissue metabolic activity"  Apolipoprotein C3 (APOC3) is a small glycoprotein in blood, secreted by the liver and intestine. APOC3 plays important role in plasma triglyceride metabolism since numerous epidemiological and animal studies have established a direct correlation of plasma APOC3 levels to plasma triglyceride levels. Based on this important function of APOC3, silencing antisense oligonucleotides targeting Apoc3 expression are currently in clinical trials for the treatment of hypertriglyceridemia and its related pathologies.  In...

EVACETRAPIB: Another Failed Hdl-Cholesterol Raising Drug

EVACETRAPIB: Another Failed Hdl-Cholesterol Raising Drug

21 May 2017

Since 2006 I have been preaching that, based on our data and critical review of published literature, simply raising HDL cholesterol (HDL-C) levels is a failed strategy in the fight against coronary heart disease. Rather, our data suggest that improving HDL particle functionality is the proper strategy and of course requires a deep understanding of the structure-function relationship of HDL. Often times I felt very lonely going against the prevailing view and the billions of dollars invested in HDL-C raising drugs. However, our data have been indisputable. So, I never looked the other way.In 2013, in a manuscript published in...

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+302610969120 +302610997940
medpharmasec@upatras.gr
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