The laboratory of
Prof. Kyriakos E. Kypreos

Exploring the exciting world
of lipids and lipoproteins
for better health

The laboratory of
Prof. Kyriakos E. Kypreos

Clinical Pharmacology and Therapeutics

The laboratory of
Prof. Kyriakos E. Kypreos

Preclinical Research in animal models

The laboratory of
Prof. Kyriakos E. Kypreos

Consulting
Post-market evaluation
Product safety assesment

The laboratory of
Prof. Kyriakos E. Kypreos

Ideas and innovation
for healthy living

Research

Publications

e-Learning

Services

Image
In my research laboratory currently located at the University of Patras Medical School, we have been performing research in lipidology for over 20 years. Using unique animal models and advanced molecular approaches coupled with modern gene transfer methodologies, we explore the exciting world of lipoproteins for better health.
Our preclinical studies aim at unraveling the molecular links between the lipoprotein transport system and metabolic conditions such as dyslipidemia, obesity and diabetes. Among others, we place particular interest in the role of the lipoprotein system in adipose tissue metabolic activity. Ultimate goal of our studies is the identification of novel pharmacological targets and the creation of individualized therapies for an array of pathological conditions.
Our clinical studies focus on the better understanding of pharmacotherapy and the potential synergism between therapies for increased therapeutic efficacy. Along these lines, we provide consulting services to the Pharmaceutical industry, for post-marketing evaluation and safety assessment of their products. To increase the impact of our work, the scientists of my research team come from different disciplines of biomedical research, contributing to an interdisciplinary approach to all projects.
In this website you will be introduced to the members of the lab, our representative publications in international peer-reviewed journals, the research services we provide and the most important news from our lab and around the world. I strongly encourage you to take the time and watch our educational videos located in the e-Learning section of our site. These videos provide a close-up look at our most recent and novel research findings.

I would like to thank you for taking this virtual tour around my lab. I hope that you enjoy surfing our website.


kyriakos kypreos signature

What’s New

BBA Molecular Basis of Disease, accepted for publication our paper entitled “Site-specific effects of apolipoprotein E expression on diet-induced obesity and white adipose tissue metabolic activation”

BBA Molecular Basis of Disease, accepted for publication our paper entitled “Site-specific effects of apolipoprotein E expression on diet-induced obesity and white adipose tissue metabolic activation”

14 November 2017

There is a wide perception among broader scientific community that Apoe promotes obesity via promoting direct lipid delivery to adipose tissue in the periphery [1]. This is based on the knowledge that lipoprotein-bound Apoe is a natural ligand for Ldlr and Lrp1 [2-4].However, Ldlr has only a minor, if any, contribution to diet-induced obesity [5,6]. Similarly, despite reports suggesting that adipose tissue Lrp1 may be implicated in diet-induced obesity [7], more recent work [8,9]showed that in the aP2-cre mouse, significant Cre activity is also found in ganglia of the peripheral nervous system (PNS), in adrenal medulla and in neurons throughout the central nervous system (CNS), proving that the...

Our manuscript entitled ‘High-Density Lipoprotein (HDL) metabolism and bone mass’ is now featured in the Journal of Endocrinology educational resources - JBL (Journal Based Learning)

Our manuscript entitled ‘High-Density Lipoprotein (HDL) metabolism and bone mass’ is now featured in the Journal of Endocrinology educational resources - JBL (Journal Based Learning)

03 August 2017

Our manuscript ‘High-Density Lipoprotein (HDL) metabolism and bone mass’ recently accepted for publication in the Journal of Endocrinology (IF=4.71, Official Journal of the Society for Endocrinology) has been selected to be featured in the journal’s educational resource – Journal Based Learning (JBL). JBL is being introduced to help educate clinicians-in-training and junior researchers. It is based upon leading articles published in the Journal of Endocrinology that form the evidence for continuing professional development programmes. Congratulations to all contributors for their good work!

Apolipoprotein C3, a critical apolipoprotein for hypertriglyceridemia, exerts pleiotropic effects on HDL Functionality and Adipose Tissue Metabolic Activity

Apolipoprotein C3, a critical apolipoprotein for hypertriglyceridemia, exerts pleiotropic effects on HDL Functionality and Adipose Tissue Metabolic Activity

14 July 2017

The Journal of Lipid Research, the official lipidology journal of ASBMB, yesterday published our work on the "Pleiotropic effects of apolipoprotein C3 on HDL functionality and adipose tissue metabolic activity"  Apolipoprotein C3 (APOC3) is a small glycoprotein in blood, secreted by the liver and intestine. APOC3 plays important role in plasma triglyceride metabolism since numerous epidemiological and animal studies have established a direct correlation of plasma APOC3 levels to plasma triglyceride levels. Based on this important function of APOC3, silencing antisense oligonucleotides targeting Apoc3 expression are currently in clinical trials for the treatment of hypertriglyceridemia and its related pathologies.  In...

CONTACT

Contact us
+302610969120 +302610997940
medpharmasec@upatras.gr
Monday-Friday 10:00-17:00
Saturday & Sunday: closed

NEWSLETTER

FOLLOW US

LIKE US

© Copyright 2013 - 2017 The laboratory of Prof. Kyriakos E. Kypreos at the University of Patras Medical School | Designed by IntelSoft